I am trying something new here. A new case each month will be presented with hope of presenting a Case of the Week if there is interest in doing so. Readers can respond with comments or diagnoses for a particular case and share their opinions.
I would be happy to post any interesting cases if you can provide a brief clinical history, whole slide images and diagnosis.
October’s case involves a case I reviewed in consultation. The patient is a 54 year old man who presented with abdominal pain and was found to have a large retroperitoneal mass involving the pancreas and transverse colon.
Sections from the tumor showed conspicuous areas of well-differentiated liposarcoma (slide 3). In addition, there were focal whorls identified composed of tightly, concentrically arranged, ovoid to spindle cells showing plump vesicular nuclei, eosinophilic nucleoli and scant amphophilic cytoplasm (slide 2). One of the sections also showed areas of bone formation (slide 1).
The diagnosis and a reference are below the images.
Enjoy! And thanks in advance for your comments!
Dedifferentiated liposarcoma with neurallike whorling pattern and metaplastic bone formation.
Nascimento AG, Kurtin PJ, Guillou L, Fletcher CDM. Dedifferentiated liposarcoma. A report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. AJSP 1998; 22(8):945-55.