Predicting Cancer Survival Using Multi-marker, Computer-Aided Method to Determine Phenotypes of Lymphocytes in Melanoma Tissue Sections
The capacity of lymphocytes to infiltrate tumors is essential for T-lymphocyte-mediated tumor destruction and a high degree of tumor-infiltrating lymphocytes (TILs) is associated with a better prognosis. An understanding of the phenotype and spatial distribution of TILs within tumor regions would be valuable for characterizing host response.
PerkinElmer’s novel multi-marker and counting approach using the Vectra® multispectral imaging system and inForm® analysis software shows the potential for broad applicability in the assessment of TILs in melanoma sections.
View our application note ‘Phenotyping of Tumor-infiltrating Lymphocytes in Melanoma using Multiplexed Immunohistochemistry and Automated Tissue Analysis’ to learn more.
Highlights of application note include:
- Predicting cancer survival through the characterization of tumor-infiltrating lymphocytes in FFPE tissue
- High throughput image analysis of melanoma tissue microarray (TMA) cores
- Automated quantitation of multi-color immunohistochemical stains using Vectra and inForm