An Automated and Robust Approach to Mitotic Counting

| November 12, 2014

visiopharm11-14Determining the mitotic activity in Haematoxylin and Eosin (H&E) is known to be difficult, time-consuming and associated with problems of reproducibility in differentiating mitotic figures from apoptotic cells, necrotic cells or karyorrhexis. By using the biomarker Phosphohistone H3 (PHH3) which expresses cells in the late G2 and M phase, new automated methods for mitotic counting can be implemented.

Join Visiopharm on November 18, 2014 at 4:00 PM CET/ 10 AM EST/ 7 AM PST for our webinar “Mitotic Counting: An Automated and Robust Approach.”

Click here to register and learn more about this exciting approach.

Visiopharm has developed a novel, patent protected method that allows you to calculate the mitotic count of PHH3 in a robust, automated and quantitative way. Virtual Double Staining allows you to determine both the mitotic count and index within the area of the tumor automatically e.g. in 10 high power fields. When estimating the mitotic index, the total number of both positive and negative cells must be determined. Virtual double staining gives you the possibility of calculate the mitotic index by identifying thousands of cells using image analysis and only within the tumor area.

This webinar will present the Virtual Double staining method and how it is used for automatic tumor detection and quantification of the mitotic count and index within the tumor area. Recent results from clinical data will be presented together with a live demo. The live demo will contain a quantification of the PHH3 mitotic index in breast tissue using the Virtual double staining approach where thousands of cell profiles are analyzed in a wizard driven workflow.

Click here to attend the live event. If you cannot attend, register anyway and Visiopharm will send you a link to the recorded webinar after the live broadcast.

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