Introducing The NeoSITE Cervical FISH Panel

| September 24, 2015
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NeoSITE™ Cervical FISH Panel
We are pleased to introduce the NeoSITE™ Cervical FISH Panel to aid diagnosis, classification, and monitoring progression and regression of cervical lesions including ASCUS, LSIL, HSIL, and CIN. Global and tech-only testing is now available.

The NeoSITE Cervical FISH Panel, performed on ThinPrep® cytology samples, serves as an adjunct to cytology and HPV nucleic acid analysis. The Panel determines copy numbers of five genomic loci that show non-random gains in pre-cancerous and cancerous cervical lesions. These gains have been associated with progression of cervical cancer. Circumstances in which FISH testing may be considered include:
  • Ambiguous cytology on Pap smear (e.g. ASCUS, LSIL, HSIL)
  • Discordant cytology and HPV status
  • To differentiate high-risk vs. low-risk LSIL
  • Decision-making for colposcopy vs. monitoring and repeat Pap
  • Monitoring pre-cancerous lesions
  • Any clinical scenario calling for an additional prognostic indicator

This is the only five-probe assay commercially available to evaluate chromosomal imbalances in cervical cancer. In validation studies, this test demonstrated genomic instability in 98% of HSIL/HPV-positive lesions. Testing should be coordinated with HPV genetic analysis and cytology. Check out our other Women’s Health Molecular Tests.

Educational Webinar
A recorded presentation entitled NeoSITE Cervical FISH Panel is available for viewing at your convenience through our NeoUNIVERSITY Training Website (free registration required). This webinar is about 15 minutes in length and includes orientation to the probes, signal patterns, and interpretation of results.
Targeted Chromosomal Regions
  • Centromere 7 (7p11.1-q11.1)
  • D5S630 (5p15)
  • MYC (8q24)
  • TERC (3q26)
  • ZNF217 (20q13)
Ordering Information
  • Specimen requirements:
    • Cervical specimens in ThinPrep® Pap Vial
    • Please note we cannot accept SurePath™ specimens at this time. We are working to add this option.
    • Do not use APTIMA® Specimen Transfer tubes for ThinPrep® samples with this test.
    • Samples must be delivered to NeoGenomics within 21 days of collection.
  • Turnaround time: 5 days
  • CPT: 88374×2 antomated or 88377×2 manual
  • A printable test summary is available here

As always, we appreciate your business and are happy to hear from you. Call us at 866-776-5907 or email

Please note this test is not yet available to New York clients. The CPT codes provided are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

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Category: Anatomic Pathology, Business, Clinical Laboratories, Clinical Pathology, Device Manufacturers, Laboratory Management & Operations, Marketing, Pathology News, Webinars

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