Case Study using HALO™ and STRATA™: Biomarkers of Anti-Tumor Immune Activity Associate with Survival in Melanoma
Wednesday September 28th | 8 AM PDT | 11 AM EDT | 4 PM BST
Dr. Tricia Cottrell, Johns Hopkins Medical School
Vlado Ovtcharov, Indica Labs
PD-L1 expression in the tumor microenvironment can be both prognostic and predictive. PD-L1 expression is often a marker of an ongoing CD8+ cytotoxic T-cell-mediated anti-tumor immune response, and thus, patients with PD-L1-positive melanomas have improved overall survival relative to those with PD-L1- negative melanomas. PD-L1 expression and high CD8-T-cell density have also been associated with an increased probability of response to PD-1 pathway blockade therapies in melanoma.
In this webinar, Dr. Cottrell and Mr. Ovtcharov will describe recent studies using digital image analysis with Indica Labs’ HALOTM and STRATATM platforms to characterize immunohistochemical features of the tumor microenvironment and correlate them with survival for patients with melanoma.
Dr. Cottrell’s Bio
Dr. Tricia Cottrell from Johns Hopkins School of Medicine is a post-doctoral fellow in the lab of Dr. Janis Taube. Dr. Taube’s laboratory described PD-L1-mediated adaptive immune resistance by melanoma, a finding that has now been extended to other tumor types. She also developed a robust immunohistochemistry assay and interpretation methods for studying PD-L1 as it relates to therapeutic response. Versions of this assay are now approved by the U.S. Food and Drug Administration for clinical use. Dr. Cottrell’s work in the Taube lab focuses on the use of digital image analysis platforms for quantitative characterization of biomarkers in the tumor microenvironment for improve prognostic and predictive applications.
Meet us in person at the following conferences this fall:
Society of Histotechnology – Long Beach CA | September 17th-20th
European Society of Toxicologic Pathology – Barcelona Spain | September 20th-23rd
2016 Pathology Visions – San Diego CA | October 23rd-25th
Society of Immunotherapy for Cancer – National Harbor, MD | November 9th-13th
UK Digital Pathology Congress– London UK | December 1st-2nd
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