Nature Cancer publication alert: Harvard study reveals prognostic spatial biomarkers for colorectal cancer
Read how Orion™ was used to identify improved prognostic signatures for colorectal cancer patients in this publication from Harvard Medical School.
“High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers”
Lin J, Chen Y, Campton D, et al.
Harvard Medical School, Boston, MA
Combining speed and plex to generate high-fidelity quantitative data across whole slides, this study of seventy-four (74) human colorectal cancer resections (100 million+ cells) utilized automatic generation and ranking of spatial biomarkers, revealing those that are highly predictive of progression-free survival.
Using the rigorous, subcellular quantitation uniquely enabled by the Orion platform, combined with same-section H&E, the research team was able to identify a spatial biomarker with a hazard ratio of ~0.045, which would make it significantly more predictive than the existing Immunoscore*.
Watch the webinar describing this new study
Multimodal tissue imaging and machine learning to advance precision medicine
Dr. Peter K Sorger, Harvard Medical School
